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,Page Top,,Let's talk to people,Is NMN really effective,Objective of DO - HEALTH,,Shopping and Dining for Foreign Visitors,(Shinjuku,Shibuya, Ginza 1-4Chome, Ginza 4-8Chome,Where to go, by purpose,Where to go, by region in ABC order,),Table of Contents in English,

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画面ＴＯＰ、All Subway Station Name in ABC Order and Map,All Subway Station Name in Line order and Map,JR Stations Name in ABC order and in Line Order and Map ,Highway Bus Stop Name in ABC Order and Terminal Location,Highway Bus Terminal Location and Bus Stop Name ,20 Most Favoured Sightseeing Spots in Tokyo in 2023,Map of Major Districts by Name in ABC Order & by Area ,Popular Events in Tokyo for One Year,Underground Passage Map of Major Cities, Table of Contents in English,
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、東京地下鉄路線図、,東京JR路線図、東京主な地図配置図、地域目次、本頁見出し（記事訪日外国人向け有名店での買物・食事：新宿,渋谷、銀座１－４丁目、銀座４－８丁目、訪日外国人の買物・食事（目的別）、訪日外国人の買物・食事（地域別）、詳細目次：東京主な地図配置図（地域別、あいうえお順）、地域目次（ABC順）、ライフサイエンス、社会・経済、東京五輪2020、各県のアンテナショップ、地下通路・出口一覧、都内高速バス乗場と行先一覧、高速バス行先別一覧、年間行事予定表、１-３月、４-６月、7-８月、９月-12月、詳細目次（東京あ-か、東京さ、東京た-わ、他府県）、年間行事予定、新規追加・更新、）

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人々と話をしよう

1.日本には新聞、TV、雑誌など様々なメディアがあり、毎日情報が発信されているので、日本の現状について人々がはっきり認識しているだろうと思うと、必ずしも正しく理解されていない。

この為に票を稼ぐために少しでも多く消費税を下げることに頑張っている政党が多い、これに対して「国債の金利が上がることが日本にとっていかに大変なことか分かっていない」と答えるだけでは、一般の日本人に理解して貰うのは難しい。

貧しい家庭では親の稼ぎが足りないからと言って子供が親に向かって文句を言うことは無い。なぜなら、自分たちの状況は日々の生活を通して十分に理解しているから。

政治家の方々と国民の間には家族と同様にお互いの理解が必要になる。この説明が難しいのは理解できるが、出来るだけ努力をすることが必要で、政治家の方々が努力をされればされるほど国民の間には正しい理解が広がるのは間違いない。

「政治家と国民の関係は、民主主義の根幹をなす重要なものです。簡単に言えば、政治家は国民の代表であり、国民は政治家を選び、監視する存在です。（Copilot)」
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NMNは本当に有効か、

１.　アメリカ食品医薬品局（FDA)は、NMNの食品やサプリメントとしての販売を２０２２年１０月に禁止しました。その理由は、NMNが新薬として調査中である為です。アメリカでは、新薬として認められると、その成分は医薬品のみに使用でき、サプリメントとしての販売はできなくなります。この規制は、NMNが危険だからではなく、医薬品としての承認プロセスの一環として行われたものです。日本ではNMNの販売は合法であり、食品として分類され販売されています。

NMNの効果については、米国ワシントン大学の今井真一郎教授らがマウスを使って研究し、酵素「サーチュイン」が、老化や寿命を制御していることを発見し、老化に伴うサーチュインの減少をＮＭＮの摂取により補うことで老化を遅らせることを発見した。生後５か月から１年間、マウスにNMNを飲ませたところ、ヒトの６０代に相当する１７か月齢になっても、体の代謝が保たれて、中年太りせず、若い時と同じように活発に動き、骨格筋、肝臓、脂肪において加齢に伴って起こる遺伝子の変化が抑えられるなど、抗老化効果がみられたというのだ。

NMNを飲ませたマウスは、飲まなかった対照群に比べて、血糖値を下げるインスリン感受性が高く、老化に伴って低下する目の網膜の機能、骨密度、免疫細胞が保たれるなどの抗老化効果も確認された。また、他のグループによるマウスを用いたアルツハイマー型認知症の研究では、NMNを１０日間飲ませただけで認知機能が回復し、記憶を司る脳の海馬の細胞死が健康なマウスに近いレベルに回復したと報告されている。(Beyond Health,project.nikkeibp,co,jp)
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DO-HEALTH臨床試験
１．DO-HEALTHの目的

DO-HEALTHは、ヨーロッパの高齢者の健康維持を目的とした大規模なランダム化臨床試験です。この研究では、ビタミン　D、オメガ　３　脂肪酸、簡単な自宅運動プログラムが、病気の予防や健康寿命の延長にどのように寄与するかを調査しています。（Copilot）

参考：米国でも「ビタミンD及びオメガ-3試験(VITAL)の主な結果と関連するビタミンD試験の最新のメタアナリシス」で同様なレポートが出されています。これによると、ビタミンD3（2,000IU）,
海洋性オメガ３脂肪酸（1g)を毎日摂取、にて行われた結果ではビタミンD は総浸潤（ガン細胞が境界を越え、周囲の組織に浸みこんでいる）ガン発症率を有意に低下させなかったが、総癌死亡率の低下については有望なシグナルを示した。
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新宿、(東口/西口/南口/新南口)

新宿は、元々新宿駅がある周辺が中心であったが、駅を発着する機関車の煙を避ける為に、新宿３丁目交差点周辺が賑わいの中心となり、やがて機関車から電車に変わる事により、新宿駅周辺に賑わいが戻って来た。この結果新宿駅と新宿３丁目の間がショッピングその他の中心になった。

その後西口の淀橋浄水場跡が高層ビル街に変わり、都庁、三井ビル、住友ビル、京王プラザホテルが建てられ、また、電気量販店のヨドバシカメラが店舗の数を増やして電気製品販売の中心地となっていった。

南口は他の地域よりは静かな地域であったが、高速バスを集約した「バスタ新宿」が出来て人の流れが南口、新南口へと流れて来るようになった。
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English Map	Where to go	Photo,Explanation
Shinjuku 新宿 English Map	都庁、東京ガイド Tokyo Metropolitan Gov. Bldg,1st, Floor,Information Center	Photo,Explanation
Shinjuku 新宿 English Map	新宿駅南口、東京ガイド JR South Exit , under the Koshu Kaido Street bridge, Information Center	Photo,Explanation
Shinjuku 新宿 English Map	伊勢丹 Isetan,,Department Store Clothes,Restaurants,Food Sales at B1F	Photo,Explanation
Shinjuku 新宿 English Map	新宿中村屋,Restaurant Shinjuku, Nakamuraya, Rice and Curry	Photo,Explanation
Shinjuku 新宿 English Map	思い出横丁 Omoide Yokocho ,Beer and Yakitori	Photo,Explanation
Shinjuku 新宿 English Map	都庁、見晴らし Metropolitan Gov's Bldg, Command Good View,Free	Photo,Explanation
Shinjuku 新宿 English Map	新宿御苑 Shinjuku Gyoen, Ex. Royal Garden,Entrance Fee required	Photo,Explanation
Shinjuku 新宿 English Map	高島屋、高島屋タイムズスクエア New　South　Exit、Takasimaya、Takasimaya　Times Square	Photo,Explanation
Shinjuku 新宿 English Map	バスタ新宿 Busta Shinjuku, Highway Bus Terminal	Photo,Explanation
Shinjuku 新宿 English Map	ビックカメラ、ユニクロ、Shinjuku Station East Eit Bic　Camera,　Electric Appliances　Shop Uniqlo,,Casual Wear	Photo,Explanation
Shinjuku 新宿 English Map	紀伊国屋書店、 Kinokuniya Book Store Many English Books	Photo,Explanation
Shinjuku 新宿 English Map	世界堂、Sekaido,　Various Painting Goods	Photo,Explanation
Shinjuku 新宿 English Map	コクーンタワー,モード学園Cocoon Tower	Photo,Explanation
Shinjuku 新宿 English Map	新宿　NS　ビル、 Shinjuku NS Bldg, World Largest Pendulum Clock	Photo,Explanation
Shinjuku 新宿 English Map	東京医科大学病院、Tokyo Medical Univ. Hospital	,Photo,Explanation

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英語版　（English Version）,
Shopping, dining, etc. for foreign visitors

１　Let's talk to people

1. In Japan, there are various media such as newspapers, TV, and magazines, and information is disseminated every day, so you might think that people have a clear understanding of the current situation in Japan, but it is not necessarily correctly understood.

For this reason, many political parties are working hard to lower the consumption tax as much as possible to gain votes, and it is difficult to get ordinary Japanese people to understand by simply replying, "You dont't understand how difficult it is for Japan if interest rates on national bonds rise."

In poor families, children do not complain to their parents just because their parents do not earn enough. This is because they fully understand their situation through their daily lives.

Politicians and the public need to understand each other, just like families. I understand this explanation is difficult, but it is necessary to make as much effort as possible, and the more effort politicians make, the more correct understanding will surely spread among the public.

The relationship between politicians and people is very important and forms the foundation of democracy. Simply put, politicians are "representative of the people" and the people "are the ones who choose and monitor politicians"（Copilot)
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Is NMN really effective?

1.The US Food and Drug Administatiopn (FDA) banned the sale of NMN as a food or supplement in October 2022. The reason is that NMN is under investigation as a new drug. In the United States, if it is approved as a new drug, the ingriedient can only be used in medicines and cannot be sold as a supplement.

This regulation was not made because NMN is dangerous, but as part of the approval process as a medicine. In Japan, the sale of NMN is legal and it is classified as a food.

Professor Shinichiro Imai of the University of Washington in the United States and others conducted research on the effects of NMN using mice and discovered that enzyme "sirtuin" controls aging and lifespan, and discovered that aging can be delayed by supplementing the decrease in sirtuin that occurs with aging through the intake of NMN. When mice were given NMN for one year from five months after birth, they maintained their body metabolism even at 17 months of age, which is equivalent to a human in their 60s, and were as active as when they were young. The genetic changes that occur with age in skeletal muscles, liver, and fat were suppressed, and anti-aging effects were observed.

Mice given NMN had higher insulin sensitivity, which lower blood sugar levels, compared to a control group that did not drink NMN, and anti-aging effects were confirmed, such as maintaining retinal function, bone density and immune cells, which decline with age. In a study of Alzheimer's disease using mice by another group, it was reported that cognitive function was restored by giving NMN to mice for just 10 days, and cell death in the hoppocampus, the part of the brain that controls memory, was restored to a level close to that of healthy mice. (Beyond Health, project. nikkeibp, co,jp)

In addition, Dr.Sinclair,who published "Life Span," takes 1,000mg of NMN, 1,000mg of metformin, a diabetes treatment drug, as it is effeictive in preventing aging, and 1,000mg of resveratrol every day and says that even now at the age of 55, he is healthier than he was at 20.

Dr.Sinclair is trying to prove the effects of NMN、metformin, and resveratrol on longevity using his own body, but since dying from cancer or a stroke would prevent him from proving it, he is extremely mindful of his daily lifestyle. He emphasizes the importance of exercise, recommends fasting, and adovocates a plant- based diet-particularly broccoli sprouts, legumes, tofu and natto, turmeric, and matcha.

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Objective of DO-HEALTH

DO-HEALTH is a large-scale randomized clinical trial aimed at maintaining the health of older adults in Europe. The study is investigating how vitamin D, omega-3 fatty acids, and a simple home exercise program contribute to disease prevention and healthy life expectancy.(Copilot)

Reference:A similar report was published in the United States in "Key Results of the Vitamin D and Omega-3 Trial (VITAL) and Latest Meta-Analysis of Related Vitamin D Trials." According to this, results of daily intake of vitamin D3 (2,000IU) and marine omega-3 fatty acids (1g) showed that vitamin D did not significantly reduce the incidence of total invasive cancer (cancer cells crossing the border and infiltrating the surrounding tissue), but showed promising signals for reducing total cancer mortality.

2. Results of DO-HEALTH:

Prevention of infections: Intake of omega-3 fatty acids reduces of infections, In particular the risk of acute upper respiratory tract infections and urinary tract infections is reduced.

Improved blood pressure: Vitamin D intake reduced systolic blood pressure in participants aged 70-74 years.

Fall prevention: Omega-3 fatty acid intake reduced the rate of falls by 10%.

Prevention of pre-frailty: The combination of vitamin D, omega-3 fatty acids, and a simple home exercise program (SHEP) reduced the risk of pre-frailty by 39%.

The combinationof these three reduced the incidence of invasive cancer by 61%.

3. Health habits that help with DO-HEALTH

1)Vitamin D intake: Helps maintain bone health and improve immune function.

Supplementing through sunlight, diet, and supplements should be 800-2000 IU per day.

Reference: Nature Made Super D is 1,000IU per day.

2) Omega-3 fatty acid intake: Effective in suppressing inflammation and preventing cardiovascular disease. It can be obtained from fish (salmon, tuna, sardines) and nuts (walnuts, chia seeds). The recommended intake is about 1-2g per day.

①Flaxseed oil: One teaspoon contains 4.6g of flaxseed oil and 2.47g of omega-3 fatty acids, so about half a teaspoon will provide 1.24g of omega-3.

②Canned mackerel contains 1,310mg of DHA and 848mg of EPA, for a total of 2,158mg of both. If you eat about 50g of mackerel, one table spoon is 15g, so you'll need more than three tablespoons of mackerel.

③ One capsule of Nature Made Super Fish Oil cotains 162mg of EPA, and 108mg of DHA, for a total of 0.27g of both, so one capsdule of the supplement is not enough.

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Shopping, dining, etc. for foreign visitors
Shinjuku, (East Exit/West Exit/South Exit/New South Exit)

Shinjuku was originally centered around Shinjukui Station, but to avoid the smoke from locomotives arriving and departing from the station, the area around Shinjuku 3-chome intersection became the center of acitivity. Eventually, the area changed from locomotives to electric trains, and activity returned to the area around Shinjuku Station. As a result,the area between Shinjuku Station and Shinjuku 3-chome became the center of shopping and other activities.
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English Map	Where to go	Photo,Explanation
Shinjuku 新宿 English Map	都庁、東京ガイド Tokyo Metropolitan Gov. Bldg,1st, Floor,Information Center	Photo,Explanation
Shinjuku 新宿 English Map	新宿駅南口、東京ガイド JR South Exit , under the Koshu Kaido Street bridge, Information Center	Photo,Explanation
Shinjuku 新宿 English Map	伊勢丹 Isetan,,Department Store Clothes,Restaurants,Food Sales at B1F	Photo,Explanation
Shinjuku 新宿 English Map	新宿中村屋,Restaurant Shinjuku, Nakamuraya, Rice and Curry	Photo,Explanation
Shinjuku 新宿 English Map	思い出横丁 Omoide Yokocho ,Beer and Yakitori	Photo,Explanation
Shinjuku 新宿 English Map	都庁、見晴らし Metropolitan Gov's Bldg, Command Good View,Free	Photo,Explanation
Shinjuku 新宿 English Map	新宿御苑 Shinjuku Gyoen, Ex. Royal Garden,Entrance Fee required	Photo,Explanation
Shinjuku 新宿 English Map	高島屋、高島屋タイムズスクエア New　South　Exit、Takasimaya、Takasimaya　Times Square	Photo,Explanation
Shinjuku 新宿 English Map	バスタ新宿 Busta Shinjuku, Highway Bus Terminal	Photo,Explanation
Shinjuku 新宿 English Map	ビックカメラ、ユニクロ、Shinjuku Station East Eit Bic　Camera,　Electric Appliances　Shop Uniqlo,,Casual Wear	,Photo,Explanation
Shinjuku 新宿 English Map	紀伊国屋書店、 Kinokuniya Book Store Many English Books	Photo,Explanation
Shinjuku 新宿 English Map	世界堂、Sekaido,　Various Painting Goods	Photo,Explanation
Shinjuku 新宿 English Map	コクーンタワー,モード学園Cocoon Tower	Photo,Explanation
Shinjuku 新宿 English Map	新宿　NS　ビル、 Shinjuku NS Bldg, World Largest Pendulum Clock	Photo,Explanation
Shinjuku 新宿 English Map	東京医科大学病院、Tokyo Medical Univ. Hospital	,Photo,Explanation

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年間行事詳細別紙（日時、場所、地図他）画面ＴＯＰへ、１-３月、４-６月、7-８月、９月-12月、京都年間行事、
新規追加・更新：画面ＴＯＰへ、軽井沢、深大寺、神代植物公園、王子・飛鳥山、「携帯で写真を見ながら街歩き」目的地の地図と訪問先の画像を画面メモにすることをお勧めします。待合せ場所の特定に便利です。

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